James Gomes Selected Research

angiogenin

1/2021	A distant angiogenin variant causes amyotrophic lateral sclerosis through loss-of-function mechanisms: Insights from long-timescale atomistic simulations and conformational dynamics.
12/2019	Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study.
1/2019	Angiogenin mutations in Hungarian patients with amyotrophic lateral sclerosis: Clinical, genetic, computational, and functional analyses.
1/2014	Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.
6/2013	Fast prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis.
1/2013	NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networks.
1/2013	Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations.
1/2013	ANGDelMut - a web-based tool for predicting and analyzing functional loss mechanisms of amyotrophic lateral sclerosis-associated angiogenin mutations.
1/2012	Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.

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James Gomes Research Topics

Disease

14	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 01/2012
4	Infections 01/2022 - 01/2014
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2019 - 01/2013
3	Alzheimer Disease (Alzheimer's Disease) 07/2017 - 01/2013
2	Craniocerebral Trauma (Head Injury) 07/2017 - 07/2017
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2022
1	Dystonia (Limb Dystonia) 07/2017
1	Multiple Sclerosis 07/2017
1	Spinal Dysraphism (Spina Bifida) 07/2017
1	Birth Weight (Birth Weights) 07/2017
1	Wounds and Injuries (Trauma) 07/2017
1	Virus Diseases (Viral Diseases) 07/2017
1	Diabetes Mellitus 07/2017
1	Shock 07/2017
1	Hypersensitivity (Allergy) 07/2017
1	Parkinson Disease (Parkinson's Disease) 07/2017
1	Neoplasms (Cancer) 09/2016
1	Pregnancy Complications 09/2016
1	Animal Mammary Neoplasms 09/2016
1	Carcinogenesis 09/2016
1	Malaria 12/2015
1	Hypercholesterolemia 03/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2015
1	Stroke (Strokes) 03/2015
1	Rupture 11/2014
1	Breast Neoplasms (Breast Cancer) 10/2014
1	Sepsis (Septicemia) 01/2010
1	Congenital Abnormalities (Deformity) 11/2008
1	Fibrosarcoma 11/2008
1	Obesity 03/2008
1	Prostatic Neoplasms (Prostate Cancer) 03/2008

Drug/Important Bio-Agent (IBA)

9	angiogeninIBA 01/2021 - 01/2012
5	Proteins (Proteins, Gene)FDA Link 12/2015 - 01/2013
3	ribonuclease 4IBA 12/2019 - 01/2019
3	Ribonucleases (Ribonuclease)IBA 12/2019 - 01/2019
2	Heavy MetalsIBA 07/2017 - 07/2017
1	TeaIBA 07/2017
1	Epidermal Growth Factor (EGF)IBA 07/2017
1	Conjugated (USP) Estrogens (Premarin)FDA Link 07/2017
1	SolventsIBA 07/2017
1	Folic Acid (Vitamin M)FDA LinkGeneric 07/2017
1	PesticidesIBA 07/2017
1	MercuryIBA 07/2017
1	Organic Chemicals (Chemicals, Organic)IBA 07/2017
1	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 07/2017
1	HLA-DRB5 Chains (HLA DRB5)IBA 07/2017
1	Coffee FDA Link 07/2017
1	Ataxin-2IBA 01/2017
1	Caspase 3 (Caspase-3)IBA 01/2017
1	tau Proteins (tau Protein)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 12/2016
1	CalciumIBA 09/2016
1	Biological ProductsIBA 09/2016
1	Dietary CalciumIBA 09/2016
1	CationsIBA 09/2016
1	MetalsIBA 09/2016
1	Matrix Metalloproteinases (MMPs)IBA 09/2016
1	VaccinesIBA 12/2015
1	oxidized low density lipoproteinIBA 03/2015
1	PCSK9 InhibitorsIBA 03/2015
1	LDL CholesterolIBA 03/2015
1	mesoglycanIBA 12/2014
1	Peptides (Polypeptides)IBA 11/2014
1	Oncogene Proteins (Oncogene Protein)IBA 10/2014
1	Monoclonal AntibodiesIBA 10/2014
1	ProteomeIBA 01/2014
1	PresenilinsIBA 01/2013
1	Androstenedione (4 Androstene 3,17 dione)IBA 11/2008
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 11/2008
1	Bacitracin (Baci-Rx)FDA LinkGeneric 11/2008
1	gamma-sitosterol (beta-sitosterol)IBA 11/2008
1	Pharmaceutical PreparationsIBA 03/2008
1	Hormones (Hormone)IBA 03/2008
1	Finasteride (Propecia)FDA LinkGeneric 03/2008
1	Testosterone (Sustanon)FDA Link 03/2008

Therapy/Procedure

1	Art Therapy 01/2022
1	Renal Dialysis (Hemodialysis) 01/2010